Effects of low and high intra-abdominal pressure on immune response in laparoscopic cholecystectomy
Saudi Medical Journal. 2004; 25 (12): 1888-91
in English
| IMEMR
| ID: emr-68544
ABSTRACT
Immunosuppression is directly related to the degree of trauma. The aim of this study is to compare the effects of low and high intra-abdominal pressure on immune response in moderate surgical trauma. Twenty-two patients, scheduled for laparoscopic cholecystectomy, were randomly allocated to one of 2 groups according to intra-abdominal pressure low and high intra-abdominal pressure. This study was conducted in the Hacettepe University Faculty of Medicine, Operation Room, Ankara, Turkey. Serum interleukin [IL]-2 and IL-6 levels were measured. Serum IL-2 showed a significant decrease before the incision in high intra-abdominal pressure group. The increase in serum IL-6 at the end of surgery and postoperatively was lower in low intra-abdominal pressure group. These results, can be interpreted as the immune system, are less depressed when there is lower intra-abdominal pressure. This may have clinical implications in immunocompromised patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pneumoperitoneum, Artificial
/
Postoperative Complications
/
Interleukin-6
/
Interleukin-2
/
Anesthesia, General
/
Antibody Formation
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Saudi Med. J.
Year:
2004
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