Local and systemic effects of ketoprofen [a light and ultrastructural study]

ABSTRACT

Ketoprofen is one of the non steroidal anti-inflammatory drugs widely used in our population. Due to its easy access, drug abuse is very common leading to verious side effects. The effect of ketoprofen was seen on gastric mucosa and bone marrow of adult albino rats. Two regimen of the treatment were followed; either six regular interrupted doses, one week interval, given to starved rats or daily administration of the drug for six weeks. Samples from the gastric mucosa were examined both by light microscope and scanning electron microscope. Samples of the bone marrow were prepared for semithin sections, stained with toluidine blue, and examined by light microscope. Quantitative study was done using image analyser computer system. The data obtained was statistically analysed. Gastric lesions were demonstrated in both methods of treatment, although lesions were severer in chronic course. Bone marrow affection in the form of decreased granulocytic and increased erythrocytic precursors occurred only in chronically treated rats