Simple closure of perforted peptic ulcer with addition to helico bacter pylori eradication

ABSTRACT

The aim of this study was to evaluate the value of adding H. pylori antagonist to simple closure of the perforated ulcer. The study retrospectively analyzed 32 patients with perforated peptic ulcer treated by simple closure and postoperative Helicobacter pylori antagonist. Intraoperative biopsy from the edge of the ulcer revealed +ve infestation to H. pylori in all cases. Two patients had malignant ulcer proved by histopathology and were excluded from this study. The average age was 48.8 years. All patients presented within 24 hours after perforation but four patients were in shock. The morbidity rate was 0%. Three months postoperatively upper GIT endoscopy revealed healing of the ulcer in all cases [100%]. Simple closure and Helicobacter pylori antagonist resolve peptic ulcer perforation with very low morbidity and mortality