Epithelial ovarian cancer: clinico pathological features and early results of treatment of advanced stages in Suez Canal University

ABSTRACT

This study was conducted to identify the clinicopathological pattern of ovarian cancer in Suez Canal University Center of Oncology and Nuclear Medicine [SCUCON] and to assess response of advanced stage epithelial ovarian cancer to the given treatment. Ovarian cancer constituted 1.7% of all cases presented to [SCUCON] during the years 1995-2002 [74 out of 4348 cases]. Epithelial tumors accounted for 92% of them [68 out of 74 cases]. Stages III and IV accounted for 67.6% [46/68] Cytoreductive surgery was done and adjuvant chemotherapy was given to all patients.69.6% of cases [32/46] received [Cyclophosphamide + Platinol +/- Adriamycin] regimen, whereas 30.4% of cases [14/46] received [Taxol + Carboplatin]. Complete Remission [CR] was 25% and 21.4% of the 2 groups respectively, whereas partial remission [PR] was encountered in 31.25% and 42.9% of the same groups respectively. Twenty percent of both groups showed no response or stable disease. The disease progressed in 21.7% of both groups in spite of treatment. The pretreatment characteristics that remain independently significant in the analysis were; residual tumor [<1.5cm versus >1.5cm], tumor stage [III versus IV], and performance status