Utilisation de l'octreotide dans le traitement des hemorragies digestives aigues par rupture de varices oesophagiennes

ABSTRACT

Aims To asses the value of octreotide in the control of acute bleeding esophageal varices in a retrospective study Methodology: Fourty two patients admitted for esophageal voriceal bleeding confirmed at endoscopy were recruired.An initial 50 micrograms bolus of octreotide followed by a two day continuous infusion of 25 micrograms/h were evaluated for the control of bleeding. Twenty nine patients were endoscopic stigmata of recent bleeding and thirteen were active bleeding at emergency endoscopy. Octreotide was found to be effective regarding hemostasis at 48 hours and on day 7 after the index bleeding episode. 30 day mortality was 1 1,9%. Echec of octreotide was significativement associated with severity of cirrhosis [p<0, 03]. Conclusion These results suggest that octreotide is effective in the treatment of esophageal variceal bleeding and it is a valuable adjuvant treatment in association with endoscopic menagement