Lean PCOS: is it inflammatory or insulin resistant state?

ABSTRACT

The syndrome of polycystic ovary [PCOS] is one of the most frequent disorder in women [obese and lean]. PCOS is a complex and heterogenous disorder and there is still a debate for its endocrine, metabolic and inflammatory pathogenesis our aim to evaluate the insulin resistance and the inflammatory marker in lean PCOS women. A total of 28 lean women fulfilling the diagnostic criteria of PCOS compared with a 20 age and BMI matched healthy control women were enrolled in the study. C reactive protein, insulin resistance index [HOMA-IR], Adiponectin and endocrin parameters [LH, FSH, Testosterone, SHBG, 17 OH progesterone, TSH and prolactin] were measured. HOMA-IR was significantly higher in lean PCOS as compared with control group [p < 0.05], however CRP and serum adiponectin were not statistically different between the two groups. Lean PCOS is associated with insulin resistance which is independent of adiposity. Adiponectin does not seem to be actively involved in the pathogenesis of PCOS and lean PCOS is not associated with low grade inflammation