Sedation of elderly patients during endoscopic retrograde cholangiopancreatography

ABSTRACT

Patients who undergo flexible endoscopy suffer from periods of hemodynamic changes which may present risk for the development of complications. The aim of this work was to demonstrate the ability of Ketamine to reduce propofol sedative requirements, improve quality of recovery and decrease discharge time when used in the setting of ERCP in elderly patients. The study included 40 patients who were randomly divided into 2 equal groups to receive either propofol alone or propofoi-ketamine [0.25 mg.kg[-1]]. Patients were monitored for non-invasive blood pressure, three leads ECG and peripheral pulse oximetry. The total propofol dose used was compared in the two groups and time till discharge from recovery room were recorded The results showed that low dose of ketamine reduce propofol requirements used to sedate elderly patients during ERCP with significantly more stable hemodynamics, better oxygenation and earlier discharge