Comparative toxicity of flucythrinate and fenvalerate to albino rats

ABSTRACT

[R S]-alpha-cyano-m-phenoxybenzyl [S]-2-[p-[di [fluromethoxy]-phenyl]-3-methylbutyrate [flucythrinate] and-alpha-cyano-m-phenoxybenzyl]-alpha-isopropyl-p-chlorophenylacetate [fenvalerate] and their commercial formulations 30% EC and 20% EC, respectively, were tested for their subchronic dermal toxicity to albino rats at different concentrations. Flucythrinate at a level of 100mg/kg and its commercial formulation showed symptoms of parathyroid poisoning. Either flucythrinate or fenvalerate caused an elevation in both blood urea and blood glucose levels after 2 weeks of the treatment while a significant reduction in serum proteins occurred. Estimation of total serum amino acids indicated a marked reduction in glycine, cysteine and methionine confirming that these amino acids are the major conjugates of the pyrethroisd under test and their metabolites from rat tissues. The present work recommends that accidental exposure to pyrethroids for a long time might be very dangerous to man and animals