Urodynamic effects of various alpha blockers used for treatment of benign prostatic obstruction

ABSTRACT

We aimed to evaluate the effect of alpha-blockers on the urodynamic parameters of bladder outlet obstruction [BOO] and to know when to shift to more aggressive interventional procedures. Ninety patients having benign prostatic obstruction [BPO] were divided into three groups that received Doxazosin [GI], Alfuzosin [GII] and Tamsulosin [GIII]. Scores of symptoms, pressure/flow [P/F] studies and ultrasound estimated bladder weight [UEBW] were evaluated before and one year after therapy. Symptom scores and all parameters of P/F studies showed significant improvement after one year of therapy, in all groups. No significant differences were detected between treatment groups. UEBW was insignificantly decreased after therapy. 4.4% of patients were shifted to trans urethral resection of the prostate [TURP]. Alpha-blockers used for treating BPO are an effective modality of treatment not only through improving symptoms, but also through changing the P/F parameters in favour of relief of BOO. UEBW may be a promising tool for monitoring the effect of therapy