[High dose intravenous corticosteroid versus placebo in recent traumatic optic neuropathy]
Bina Journal of Ophthalmology. 2005; 11 (3): 294-300
in Persian
| IMEMR
| ID: emr-70070
ABSTRACT
To compare the effect of high dose intravenous corticosteroid therapy with placebo in the treatment of recent traumatic optic neuropathy [TON]. In double masked-placebo controlled clinical trial, 31 eyes of 31 patients were randomly assigned into two groups. Only patients with history of ophthalmic or head trauma within the past 7 days were included. Unconscious patients, with penetrating ocular injury, and candidates for decompression surgery were excluded. The treatment group [16 eyes] received 1 gr methylprednisolone intravenously for 3 days followed by 1 mg/kg prednisolone orally for 11 days. The placebo group [15eyes] received 50 ml normal saline intravenously every 6 hours for 3 days. Visual improvement was defined as increase of at least 0.3 logMAR visual acuity after 3 month. Visual improvement was achieved in 68.8% of the treatment group and 53.3% of the placebo group [P=0.1]. Visual improvement in the first 48 hours was correlated with final visual acuity [P=0.03] but final visual acuity was not significantly correlated with age [P0.06], interval from trauma to treatment [P=0.5], and initial visual acuity [P=0.06]. In patients with recent TON, high-dose intravenous corticosteroids and placebo are comparable in terms of improvement in visual acuity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Placebos
/
Steroids
/
Clinical Trials as Topic
/
Treatment Outcome
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Persian
Journal:
Bina J. Ophthalmol.
Year:
2005
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