Reversibility of fibrogenesis in teenage subjects with schistosoma mansoni and cryptosporidium parvum by therapeutic regimen

ABSTRACT

The study aims to identify the influence of young age on the magnitude of change in selected fibrogenic mechanisms, antioxidant status and immuno-inflammatory response to Schistosoma mansoni and Cryptosporidium parvum coinfection by therapeutic regimen to teenage subjects. Twenty five cases proved to be infected with S. mansoni were classified into two groups [GI including 12 subjects and GII including 13 subjects] confirming their subjection to Cryptosporidium parvum coinfection. Following the antischistosomal treatment, the therapeutic regimen evaluated herein involved monitoring the outcome of six months intake of Silymarin, cod liver oil, selenium and allium stadium. The results revealed a coordinated anti-inflammatory and antifibrotic impact linked to antioxidant scavenging potency that was implemented furthermore by the combined inhibitory effect of selenium and garlic extract on Cryptosporidium parvum which was monitored in teenage subjects after six months therapy