Synthesis of some quinoline thiosemicarbazone derivatives of potential antimicrobial activity
Bulletin of Pharmaceutical Sciences-Assiut University. 2005; 28 (1): 79-93
in English
| IMEMR
| ID: emr-70226
ABSTRACT
5-Acetyl [or 5-benzoyl]-8-hydroxyquinoline-4-substituted thiosemi- carbazones [IIa-m, IIIa-m respectively] have been prepared via the condensation of 5-acetyl [or 5-benzoyl]-8-hydroxyquinoline with the appropriate 4-substituted-3-thiosemicabazides [Ia-l]. The thiosemicarbazones [IIa-l, IIIa-f] were subjected to cyclization into the corresponding thiazolidinones [IVa-l, Va-f] by the reaction with ethyl bromoacetate in the presence of anhydrous sodium acetate. The structures of the thiosemicarbazones as well as the corresponding thiazolidinones were assigned based on both elemental and spectroscopic evidences. The prepared compounds were also evaluated for antibacterial and antifungal activities
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Biological Assay
/
Surveys and Questionnaires
/
Anti-Bacterial Agents
/
Antifungal Agents
Type of study:
Controlled clinical trial
Language:
English
Journal:
Bull. Pharm. Sci.-Assiut Univ.
Year:
2005
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