Inclusion complexes of nicardipine-HCL for oral administration
Bulletin of Pharmaceutical Sciences-Assiut University. 2005; 28 (1): 119-129
in English
| IMEMR
| ID: emr-70230
ABSTRACT
Inclusion complexes of nicardipine HCl [NIC] with beta-cyclodextrin [beta-CD] and hydroxypropyl-beta-cyclodextrin [HP-beta-CD] were prepared using different methods:
co-evaporation, kneading and co-precipitation. Inclusion complexation in aqueous solution and in solid state was studied by the solubility method, Fourier transform-infrared spectroscopy [FTIR], Differential scanning calorimetry [DSC] and X-ray diffractometry [XRD]. The solubility of [NIC] increased as a function of cyclodextrin concentration, showing B s and AL type diagrams for [beta-CD] and [HP-beta-CD], respectively. The dissolution rate of [NIC] / cyclodextrin complexes were investigated and compared with those of the physical mixtures and pure drug. The dissolution efficiency of [NIC] increased by complexation with cyclodextrins to 2.8-2.9 fold than [NIC] alone. Oral bioavailability in rabbits increased to 6 fold by complexation with [beta-CD]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
X-Ray Diffraction
/
Administration, Oral
/
Chromatography, High Pressure Liquid
/
Spectroscopy, Fourier Transform Infrared
Language:
English
Journal:
Bull. Pharm. Sci.-Assiut Univ.
Year:
2005
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