Synthesis and chemoprophylactic effect of novel coumarin derivatives

ABSTRACT

A series of coumarin derivatives carrying different biologically active side chains and heterocyclic substituents were synthesized from 8-acetyl-4-methyl-7-hydroxycoumarin. Among these side chains are alkylamino, semicarbazono- and N[4]-substituted thiosemicarbazonoethyl, I-hydrazonoethyl and substituted I-hydroximinoethyl groups, while heterocyclic substituents were derived from pyran, oxadiazole, thiadiazole and thiazolidinone rings. Also, some derivatives of pyrano [2,3-h]chromen-9-carbaldehyde were synthesized. Some of these new products were studied for their chemoprophylactic effect in Schistosoma mansoni infected mice