Synthesis, surface and thermodyanamic properties of some biologically active hexammonium bromide surfactants

ABSTRACT

A series of novel cationic surface active agent was synthesized based on hexamine and alkyl bromide derivatives as long chain quaternizing agent. The produced quaternary ammonium bromide surfactants were confirmed structurally via elemental analyses, FTIR spectroscopy and MS spectroscopy. Surface properties of the synthesized ammonium compounds were determined which include surface tension [gamma], critical micelle concentration [CMC], effectiveness [PI[CMC]], maximum surface excess [GAM[max]] and minimum surface area [A[min]] at 25 and 40°C. Thermodynamic parameters [deltaG, deltaS and deltaH] for both micellization and adsorption processes were determined. The obtained concerning surface and thermodynamic parameters were correlated to the chemical structure of the synthesized surfactants. The variations of these characteristics were found to be completely dependent on the alkyl chain length [hydrophobes]. The biological activities of target compounds were evaluated for their biological activity towards bacteria and fungi at different doses [1, 2.5 and 5mg/mI]. Good correlation was found between the surface properties and the biological activity of these surfactants