Relationship of disease severity to some biochemical markers of generalized osteoarthritis

ABSTRACT

To find out whether serum level of MMP-3, plasma level of TIMP-1 and urinary pyridinoline are specifically increased in generalized osteoarthritis [OA] or not. Also whether there is a relationship between those markers and the disease severity as detected clinically and radiologically. Thirty females suffering of generalized OA and 15 apparently healthy matched females as controls were studied. Serum MMP-3, plasma TIMP-1 and urinary pyridinoline were measured. The knee and hand joints were graded clinically [Steinbrocker] and radiologically [Kellgren and Lawrence]. Serum level of MMP-3, plasma level of TIM-1 and urinary pyridinoline were significantly higher in generalized OA patients than normal controls. The joint space width decreased with increasing Kellgren - Lawrence grade. All biochemical markers had negative correlations with the joint space width, but only urinary pyridinoline had a significant correlation. All biochemical markers had positive correlations with Steinbrocker grading. Some biochemical markers of OA may be of diagnostic value and a predictor for the severity of the disease in progressive generalized OA. The inhibition of their production and activity may decrease or delay the joint damage