Relationship between severity of airflow obstruction and isokinetic skeletal muscle strength in chronic obstructive pulmonary disease patients

ABSTRACT

Evaluate the relationship between skeletal muscle strength and severity of the airflow obstruction in patients with COPD This study included sixty patients with chronic obstructive pulmonary disease [COPD] classified into two groups [25 patients don't received steroid and 35 patient received steroid] and thirty sedentary, non smoker, healthy male as a control group. All patients and control group are subjected to Plain X ray chest, pulmonary function tests, [cross sectional area] CSA-CT scan and isokinetic measurement of [Quadriceps, Hamstring] muscles for lower limb and [shoulder abductor and adductor] muscles for upper limb. the results of this study showed that Force Expiratory Volume in one sec. FEV-1], Forced Vital Capacity FVC and PaO2 mmHg in the patients with COPD were significantly lower than control group [p<0.05]. Also, isokinetic measurement of muscles [peak torque] PT of the patients with COPD was significantly lower than control group [p<0.05]. Muscle cross section area CSA was significantly decrease in patients with COPD than control group p<0.05. Pulmonary function tests showed no significant differences in steroid and non steroid treated COPD groups. While, isokinetic measurement of muscles [peak torque] PT significantly decrease in patients received steroid than patients don't received steroid COPD group where [p<0.05]. There was relationship between COPD and muscle strength deficit which can be evaluated using isokinetic dynamometry measurement