Studies on B-lactams and thiazolidinones Part 1 Synthesis and biological activity of some new triazolyl-azetidin-2-onesand-thiazolidin-4-ones

ABSTRACT

Arylidene-3-amino-1,2,4-tiazoles [1] were prepared by condensation of 3-amino-1,2,4-triazole with aromatic aldehydes. Cyclocondensation of chloroacetylchloride, phthalinudoacetylchloride, and mercaptoacetic acid on [1] giving the corresponding azetidin-ones [2 and 3] and 4-thiaolidinones [4], respectively, in good yield