Fixed drug eruption: a descriptive study of 100 cases
Iranian Journal of Dermatology. 2005; 8 (5): 353-357
in Persian
| IMEMR
| ID: emr-71323
ABSTRACT
Fixed drug eruption [FDE] is one kind of drug rashes that is characterized by re-appearance of the lesions on the same sites after re-exposure to the causative drug. This study was performed to evaluate the epidemiologic characteristics of FDE. This descriptive study was done on a series of 100 FDE cases, who were admitted at the outpatient dermatology clinic of Hazrat-e-Rasoul Hospital over a six-year period. The primary diagnosis of FDE was suggested according to clinical findings including a remaining hyperpigmentation at the site of healed skin lesion [s]. Oral challenge test with a single low dose administration of the suspected drug was used to confirm the diagnosis. Recurrence of the lesion [s] at the same body area [s] was considered as positive result. Most commonly causative agents were co-trimoxazole and codein, which were found in 88% and 3% FDE cases; respectively. The most common site of involvement was penile glans in 57.7% of male patients and trunk in 48.3% of females. In one patient, reaction to multiple drugs including co-trimoxazole, codein and tetracycline was observed and after re-challenge with each drug, re-appearance of the skin lesion at the same site was evident. Several patients reported concomitant acetaminophen intake, but there was no reaction to that drug. Co-trimoxazole is the most common cause of FDE
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Tetracycline
/
Trimethoprim, Sulfamethoxazole Drug Combination
/
Codeine
Limits:
Female
/
Humans
/
Male
Language:
Persian
Journal:
Iran. J. Dermatol.
Year:
2005
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