Pattern of small intestinal mucosal changes in patients with type 1 diabetes mellitus

ABSTRACT

The coexistence of type 1 diabetes mellitus [DM] and Celiac disease [CD] is well recognized with a prevalence of CD in type 1 DM reported to be between 0% and 10.4%. The aim of this study was to find the pattern of small intestinal mucosal changes in patients with type 1 DM. A cross sectional study done in Al-Faiha hospital in Basrah,Iraq,on patients with type 1 DM. Duodenoscopy was done and at least four biopsies were taken from the second part of the duodenum. Four patients had normal biopsy, 16 patients had duodenitis, and 10 patients had Marsh type I. Marsh type IILA were seen in 4 patients. Marsh IIIB were seen in two patients, and Marsh IIIC in 4 patients. Marsh IIIB and C histology were regarded compatible with CD, so the incidence of CD was 15%. All patients with type 1 DM should be screened for CD-Duodenal biopsy is a relevant tool for screening CD in patients with type I DM