Alloimmune cytopenia: part II ; alloimmune thrombocytopenia, and neutropenia alloimmune thrombocytopenia

ABSTRACT

Feto-maternal alloinmmune thrombocytopenia and neutropenia occurs when the mother produces antibodies against a platelet or a neutrophil alloantigen that the fetus has inherited from the father. As a result, there is destruction of the fetal platelets or the neutrophil according to the condition and result in a reduction in their numbers. Reduction in the platelets can cause intrauterine fetal bleeding or bleeding after birth. In severe cases, this bleeding may lead to long lasting disabilities. In the case of neonatal neutropenia the reduction of the neutrophils will increase the susceptibility to serious infectious. Current advances in management attempts at the prevention of thrombocytopenia and neutropenia in the fetus. This includes administration of intravenous immunoglobulin corticosteroids, or intrauterine transfusion of antigen-compatible platelets or neutrophils to the fetus. The management is costly and requires specialized labs and skilled perinatal and neonatal care