Synthesis of some new C-5 aryl pyrimidine nucleosides

ABSTRACT

Due to the vital role of thymidylate synthetase as the sole route to thymidylic acid, a precursor for DNA synthesis, its inhibition has afforded an opportunity to control certain cancers and viral infections Several effective agents for its inhibition are currently utilized chemotherapeutically including 5-fluoro-, and 5-iodch2-deoxynridine. There is a great need, however, for new designed agents for improved therapy that are less cytotoxic to normal tissue. Pyrimidine nucleosides substituted at position 5 have high potential in this respect. Recently, we have reported the photochemical synthesis of C-5 substituted aryl, heteroaryl and alkyl pyrimidine nucleosides. The aim of this paper is to report the synthesis of some new 5-aryl pyrimidine nucleosides using this photosubstitution reaction