acid hydrolysis of formamide in water-acetone mixtures

ABSTRACT

The acid hydrolysis of formamide is studied in an extensive series ranging from pure water up to 75 percent by weight acetone at the temperature range 25-50 degree. A minimum is observed at 0.17 mole fraction of acetone. The reaction is found to be electrostatically independent and the results are discussed in the light of the role of water in the mechanism of the reaction and its structural chance in the mixed solvent. The thermodynamic properties of the activated complex are calculated and discussed in terms of the solvation effects