Effect of vitamin C supplements on patients with hypertension
Journal of Qazvin University of Medical Sciences and Health Services [The]. 2005; 35 (Summer 2005): 94-98
in Persian
| IMEMR
| ID: emr-72187
ABSTRACT
High blood pressure is among the established risk factor for cardiovascular disease. Vitamin C may modulate other established risk factors and processes, thereby reducing the risk of overt disease. To investigate the relationship between antioxidant vitamin C supplementation and blood pressure level in hypertensive subjects. In an experimental study [before and after study] we selected 35 hypertensive patients. Anthropometric indices were measured and BMI was calculated. Fasting blood samples were collected before and after the one-month administration of 500mg vitamin C/day. Plasma vitamin C concentration was measured using 2, 4 dinitrophenyl hydrazine and UV/vis spectrophotometer. Blood pressure was measured by 24 hr holter monitoring. A mean 3-day food records and food frequency questionnaire was analyzed by Nutrition III soft ware. The results indicated that following the one-month consumption of 500mg vitamin C/day, both SBP [p< 0.005] and DBP [p<0.003] were significantly decreased. At the same time, plasma ascorbic acid concentration showed a significant increase [p<0.005]. There was an inverse correlation between the change in SBP and the change in ascorbic acid concentration [p<0.006]. The data suggested that the consumption of 500mg ascorbic acid/day reduces both SBP and DBP in hypertensive subjects:
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Ascorbic Acid
/
Blood Pressure
/
Cardiovascular Diseases
/
Risk Factors
/
Hypertension
Limits:
Humans
Language:
Persian
Journal:
J. Qazvin Univ. Med. Sci. Health Serv.
Year:
2005
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