Effect of selenium on lipid profile of rats treated with contraceptives or certain hormone replacement therapy

ABSTRACT

Selenium play a vital part in many metabolic functions while new researches increasingly suggest it is relevance to disease prevention. Contraceptive are capable of inhibiting ovulation and successfully controlling fertility. Estrogen is a wide spread treatment in post menopousal women to alleviate climatic complaints. The present study planned to achieve three goals. First one aims to investigate some biochemical study on lipid content and side effect that occur from repeated administration of drugs [selenium, contraceptive and estrogen replacement therapy] in experimental animals. Follow up the effect on repeated administration [accumulation doses] of contraceptive on rats. Second the effect of selenium on antioxidant to amelioration any hardard effects if present. Third of them of lipid profile. Selenium was orally administered in therapeutic dose [50 micro g/kg/day], contraceptive [estrogen 540 micro g/kg/day, progesterone 2.7 micro g/kg/day] and estrogen replacement therapy [90 micro g/kg/day] to adult female albino rats ovarectomized female rats for 30 days. Repeated medication with Selenium caused significant reduction in total lipid [T.L], Triglycerid, [T.G.], total cholesterol [T.Ch.], HDL, cholesterol, LDL cholesterol and serum estradiol. Contraceptives and estrogen replacement therapy revealed very highly significant increase in T.L, T.G. T.Ch, HDL cholesterol, LDL cholesterol and estradiol When selenium was administered with contraceptives or estrogen replacement therapy, noticeable amelioration was recorded in lipid profile a slight increase was noticed in the different studied lipid parameters.