possible protective effect[s] of linseed oil against nephrotoxicity of some drugs

ABSTRACT

Linseed oil is a popular dietary element in Egypt It was found to decrease hepatic toxicity and acute lethality of acetaminophen and to decrease renal toxicity induced by gentamycin or acetaminophen [Metwally et al, 2001]. The present work aims for studying the possible protective effect[s] of linseed oil against nephrotoxicity induced by cisplatin [anticancer], cyclosporine [immunosuppressant], as well as streptomycin [amino glycoside antibiotic]. Adult male Sprague Dawely rats were fed daily by either control diet [control rats], or diet containing 5% linseed oil for 15 days. Twenty four hours later, animals of each group were subdivided into 4 subgroups and treated as follows control [drug free], cisplatin [4mg/kg i.p. X 1 day], cyclosporine [50mg/kg orally X 6 days] or streptomycin [800mg/kg i.p. X 6 days]. Seven days after administering the first dose of the nephrotoxic agents the following parameters were assessed serum creatinine and urea, glomerular filtration rate, urea clearance, serum and urine sodium and potassium as well as specific gravity and urine volume. Kidney histopathology and relative weights were evaluated. The results showed that linseed oil causes pronounced protective effect against streptomycin nephrotoxicity, slight protection against cyclosporine and very slight protective effect against cisplatin treated animals. The obtained results will be discussed in view of the possible impacts on eicosanoids and throinboxane synthesis: