Assessment of the clinical significance of serum vascular endothelial growth factor and matrix metalloproteinase-9in patients with hepatrcellular carcinoma
Journal of the Egyptian Society of Parasitology. 2005; 35 (3): 875-890
in English
| IMEMR
| ID: emr-72377
ABSTRACT
The pre-therapeutic serum levels of VEGF and MMP-9 were studied in patients with HCC, cirrhotic patients and in healthy subjects by an ELISA assay to elucidate the relationship between serum VEGF, MMP-9 levels and clinicopathological characteristics of HCC. The serum VEGF and MMP-9 were significantly elevated in HCC patients with macroscopic portal vein invasion and with metastasis as compared to HCC patients with neither invasion nor metastasis. Serum VEGF showed a significant difference between HCC patients with tumor size > 5 cm and < 5 cm, however serum MMP-9 did not vary with tumor size. It was concluded that the portal vein invasion and metastasis in HCC is a complex process involving multiple factors including VEGF-mediated angiogenesis and MMP-9 induced degradation of extracellular matrix. The pre-therapeutic serum VEGF and MMP-9 in HCC might be candidate biomarkers reflecting the disease potential for vascular invasion and metastasis, serum VEGF being a superior biomarker as it correlated also with tumor size
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Endothelium, Vascular
/
Prospective Studies
/
Endothelial Growth Factors
/
Disease Progression
/
Matrix Metalloproteinase 9
/
Vascular Endothelial Growth Factors
/
Angiogenesis Inducing Agents
/
Liver Neoplasms
/
Neoplasm Metastasis
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Egypt. Soc. Parasitol.
Year:
2005
Similar
MEDLINE
...
LILACS
LIS