Detection of altered secondary lymphoid tissue chemkine responsiveness in balb/c mice infected with schistosoma mansoni
Journal of the Egyptian Society of Parasitology. 2005; 35 (3): 1009-1017
in English
| IMEMR
| ID: emr-72387
ABSTRACT
To determine the extent to which Balb/c mice splenic T cells were affected by S. mansoni infection, this study aims to investigate the ability of the T cells to produce interferon [IFN]-alpha, and their chemotactic ability at 7 weeks postinfection. The splenic T cells were capable of producing levels of IFN-alpha comparable with splenic T cells from naive mice. However, the T cells exhibited altered chemotactic activity, as evidenced by an inability to respond to seconddary lymphoid-tissue chemokine [SLC/CCL21]. Although no difference in chemokine expression was found between the spleens of infected versus control mice, chemokine production was greater in the livers of infected versus control mice. Collectively, these data indicate that Balb/c mice with 7-wk S. mansoni infection possess splenic T cells with altered chemotactic activity and that the alterations may be a consequence of granulomatous response in the liver
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Spleen
/
Gene Expression
/
Chemotaxis
/
Interferon-alpha
/
Liver
/
Lymphoid Tissue
/
Animals, Laboratory
/
Mice
Limits:
Animals
Language:
English
Journal:
J. Egypt. Soc. Parasitol.
Year:
2005
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