Improvement of renal function after relief of chronic partial upper urinary tract obstruction

ABSTRACT

Kidney's functional and anatomical changes reversibility of after treatment of partial ureteropelvic junction obstruction [UPJO] is not defined well. Therefore, in this clinical trial study, we've evaluated these changes. In a clinical trial study with non randomized-simple sampling, 32 patients with chronic partial obstruction of urinary tract due to unilateral UPJO were studied. In each patient, IVU, DMSA, DTPA, and bilateral kidney sonography were down pre and post operatively. Paired t-test, Wilcoxon, and McNemar tests analyzed data. P-value less than 0.05 was considered significant. Mean age of the patients was 5.44 +/- 0.47 years old and 40.6% of the patients were male. Split function mean in DMSA had significant difference, comparing pre and post operatively [P<0.05]. There also was a significant difference in mean of retention time and T1/2 of DTPA [P<0.05], comparing pre and post operatively [P<0.05]. Mean of kidney pelvis diameter had significant difference, comparing pre and post operatively [P<0.05]. Our study showed that operation of chronic partial obstruction of kidney, could improve kidney function. We also showed that sonographic evaluation of kidneys could help to evaluate kidney function in these patients