effect of consanguineous marriages on congenital malformation

ABSTRACT

Consanguinity has been a long-standing social habit among some of Iranians. The estimation of consanguinity ratios in different parts of Iran ranged from 30 to 85%. This study aimed to delineating the role of consanguinity on congenital malformations in Khominishahr rural population, Isfahan, Iran. In a case-control study, 518 malformed population [case group] and 518 normal subjects [control group] were randomly selected from khominishahr rural population, from July to November, 2003. The frequency of consanguinity of parent's was 59.7% in case group and 31.5% in control group. This different was statistically significant [p < 0.001]. Family history of congenital malformation may play an important role in the high rates of congenital malformation