immune status of human persistent pyuria associated K.pneumoniae

ABSTRACT

Fifteen human persistent pyuria patients were diagnosed and investigated for their infection nature and immune status. They were associated with K.pneumoniae. The median concentrations for the total serum protein, total serum globulin, mucosal globulin, serum IgG, IgM and IgA were higher and slightly higher than normal control subjects for immunoreactive and immunocompromised persistent pyuria patients respectively. The specific anti K pneumoniae circulating and mucosal agglutinins were 360 and36 respectively in immunoreactive subjects as well as they were 200 and 40 respectively for immunocompromized patients. The leucocyte inihibitory factors were as that of normal subjects. Thus, K. pneurnoniae immunodominant epitope is being of T-independent type and/or as B cell rnitogen, both at mucosal and systemic immune responses