Role of misoprostol in dysfunccctional uterinee bleeding

ABSTRACT

This study included 128 patients between 18-49 years of age presenting with dysfunctional uterine bleeding [DUB]. They were initially assessed by general, pelvis examination as well as ultrasound of the pelvis. Women who were at high risk for endometrial cancer might be assessed by hysteroscopy and endometrial biopsy. All patients of dysfunctional uterine bleeding received misoprostol in the form of 400 mug rectally, followed by 400 mug orally every 8 hours for three days. In each cycle, the results were recorded. The efficacy of treatment was assessed in terms of a reduction in the amount of blood loss, Hb level and patient satisfaction. Also, the side effects of misoprostol in the form of GIT upset were assessed. The results showed that 128 out of 800 patients were diagnosed as having DUB. The response rate was 20.3% with misoprostol. The patient satisfaction was acceptable and its side effects were minimal