Bleomycin Induced Pulmonary Fibrosis

ABSTRACT

Bleomycin is a widely used antineoplastic drug which produces dose and time-dependent interstitial pulmonary fibrosis in human and animals. The mechanism of bleomycin-induced lung injury is not well understood. However, current studies have shown that bleomycin can generate free oxygen radicals such as super -oxide and hydroxyl radical. In this study the antioxidant effect of vitamin C in biological system and its effect on bleomycin-induced lung fibrosis in rat has been investigated. In this study rats were divided into four groups Control, bleomycin and Saline, bleomycin and vitamin C and saline and vitamin C. The degree of tissue injury in the bleomycin and vitamin C group was significantly lower than bleomycin and saline group. Results of this study suggest that vitamin C may reduce the fibrosis formation effect of belomycin in lung tissue