Comparison between single and double preovulatory intrauterine insemination for infertility treatment

ABSTRACT

To compare pregnancy rate [PR] per patient and per treatment cycle of controlled ovarian hyperstimulation [COH] patients receiving a single intrauterine insemination [IUI] with COH receiving two IUIs. 27 patients underwent 124 COH by clomiphene citrate and were randomized to receive either single or two IUIs. Single IUI group were timed 34 hours after HCG whereas double IUIs were performed 12 and 34 hours after HCG intake. Clinical pregnancy developed in 3 out of 35 patients in the single IUI group treated for 58 cycles [PR per patient and cycle was 8.7%, 5.2% respectively] compared with 11 pregnancies out of 37 patients in the double IUIs group treated for 66 cycles [PR per patient and per cycle was 29.7%, 16.7% respectively]. There was a statistically significant difference between both groups. In COH cycles, two preovulatory IUIs provide an increase in cycle PR