Association of inherited thrombophilia with pre-eclampsia

ABSTRACT

Preeclampsia and its association with thrombophilia remain controversial, due to inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this was to determine the relationship between thrombophilia and preeclamptic patients. In a prospective case-control study, we compared 50 consecutive women with preeclampsia [group 1] with 50 normal pregnant women [group 2]. All women were tested two months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase [MTHFR], and prothrombin gene mutation as well as for deficiencies of protein C, protein S, and antithrombin III. A throinbophilic mutation was found in 22 [44%] and 16 [32%] women in group 1 and group 2, respectively [P>0.05 OR 1.9, 95% CI 0.7-2.3]. The incidence of Factor V Leiden mutation [heterozygous], prothrombin mutation [homozygous] MTHFR mutation [homozygous] was not statistically significant in group 1 compared with group 2 [P>0.05]. Also, deficiencies of protein S, protein C, and antithrombin III were not statistically significant in group 1 compared with group 2 [P>0.05]. There was no difference in thrombophilic mutations between preeclamptic patients and normal pregnant women. Therefore, we suggest that preeclamptic patients should not be tested for thrombophilia