Effects of prolonged administration of large doses of ACTH on bufo melanostictus tadpoles

ABSTRACT

The present study reports the effects of different ACTH preparations, in similar and different concentrations on Bofo Melanostictus Tadpoles. ACTH administration proved antagonistic to tadpole growth hormone. There seemed to be no dose-effect response when ACTH was administered in 0.02 IU/ml instead of 0.01 IU/ml. Similar ACTH concentrations with difference of manufacture showed varied biological potency. This perhaps indicates loss of effectiveness due to change from ACTH 1-24 to ACTH 1-18 to ACTH 1-10 in descending order