Pattern of serum protein electrophoresis in various diseases

ABSTRACT

To determine the frequency and pattern of different clinical disorders on the basis of serum protein electrophoresis [SPE]. Descriptive cross sectional study. The study was conducted at the Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, during May 2003. Five hundred SPE strips [spanning over a period of one year] of patients along-with relevant clinical information were analysed to determine the frequency and pattern of clinical disorders. Out of the 500 strips analyzed, 324 were from males [mean age 53.5y] and 176 were from females [mean age 51.5 y]. Six major patterns were found including chronic inflammation [40.4%], acute phase response [20.8%], nephrotic syndrome [6.8%], paraproteinemia [9.2%], hepatic cirrhosis [0.8%] and normal pattern [21.18%]. Chronic inflammatory disease was found to be the most frequently observed pattern