Prevention of postoperative nausea and vamiting by ondansetron, In children undergoing strabismus surgery

ABSTRACT

To evaluate the antiemetic effect of ondansetron in controlling postoperative nausea and vomiting in children undergoing strabismus surgery. It was a randomized placebo controlled, double blind study of 100 children between 5-15 years of age with American Society of Anaesthesiologists [ASA] status I and II undergoing strabismus surgery under general anaesthesia.. Patients were divided into two groups of 50 each. One group was given normal saline while the other received 75ug/kg1 of ondansetron pre operatively. Children were monitored for the number of emetic episodes, and the need for a rescue antiemetic. There was significantly high P< 0.05 frequency of vomiting 30 patients 60% in group receiving normal saline when compared to ondansetron group 15 patients 30%. The incidence of early vomiting [0-4 hour] and the need for rescue antiemetic were also very low in patients receiving ondansetron when compared with the saline group. Ondansetron was found to an effective drug in preventing nausea and vomiting postoperatively in children undergoing strabismus surgery