Synthesis and biological evaluation of certain new substituted pyrido [2,3-d] pyrimidin- 4[1H] -one and pyrido [2,3-d] Triazolo [3,4-b] pyrimidine analogs

ABSTRACT

The synthesis of a new series of Pyrido[2,3-d]-pyrimidine derivatives 8-13 and their corresponding S-methyl analogs 14 pyrimidines 26, 27 are also prepared. The structures of the newly synthesized compounds have been confirmed by elemental analysis, IR, and 1H-NMR spectra. DNA-binding activity of the synthesized compounds was performed