[Abnormalities of haemostasis in myocardial infarction with normal coronary artery]

ABSTRACT

Myocardial infarction with normal coronary artery is usually inaugural, with electric and clinical characteristics similar to those with atheroma. The role of constitutional or acquired abnormalities of haemostasis has been more incriminated in the pathogenesis of myocardial infarction with normal coronary. The aim of our study was to research abnormalities of haemostasis in patients with myocardial infarction and angiographically absolutely normal coronary arteries. Thirty nine, patients with myocarcdial infarction and normal coronary arteries were included in our study. They were 33 males and 6 females aged between 22 and 75 years [44 +13 years], in whom the deficiency in protein C and S. antithrombin, activated protein C resistance and antiphospholipid antibodies were assessed Concurrent abnormalities of haemostasis were found in 10 patients Antiphospholipid antibodies, found in 5 patients constitute the most frequent abnormality. The other abnormalities were deficiency in protein C in two cases, deficiency in protein S 2 cases, deficiency in antithrombin in 2 cases and activated protein C resistance in 3 cases In our study, in face of the high prevalence of these abnormalities, it seems reasonable to research them, especially in young patients with myocardial infarction with normal coronary artery. This should have an impact on the management of these patients