arthrites juveniles idiopathiques traitees par methotrexate. Reponse au traitement et tolerance a myoen terme

ABSTRACT

The MTX has a place of choice in the treatment of the AJI with good observance and the absence of grave side effects. In a retrospective study, 14 cases of AJI having benefited from a treatment by MTX were included in the study. Answer to the treatment was estimated at the 6th month on the criteria of RINTO. The group included in the therapeutic evaluation, is formed by 10 boys and by 4 girls. The average age of the beginning of the disease is of 6 years [2 - 11]. The shape of the beginning is systematic in 7 cases and polyarticular in 5 cases and oligoarticular in 2 cases. The average duration of the treatment by MTX is of 36 months [9 - 66]. Answer to the MTX in the 6th month was noted in 7 cases, under a MTX's average dose of 7,14mg / m2 / week. Unwanted effects were observed in 7 cases and have not in any case led to the stop of the treatment