[Matanal, benefit of postpartum corticosteroid therapy in patients with HELLP [hemolysis elevated liver enzymes low platelets count] syndrome]

ABSTRACT

Our purpose was to assess the effects of corticotherapy prescribed after delivery on the kinetic of biological parameters of HELLP syndrome [hemolysis elevated liver enzymes low platelets count]. Twenty patients in whom pregnancy was complicated by antepartum or postpartum HELLP Syndrome, were randomised to receive, after delivery, either 12 mg of Dexamethasone every 12 hours for two doses [Group C, n=10], or a placebo [Group T, n=10]. Biological parameters of the HELLP syndrome were analysed just before the first bolus of either treatment [H0], then after 24, 36, 48 and 72 hours. The corticotherapy was more efficient than placebo, in the correction of the biological parameters of the HELLP syndrome. It permitted a rapid correction of the thrombopenia [from the 24th hour] but its effect on hemolysis marker was later [from the 36th hour]. The kinetic of the hepatic cytolysis marker was not modified by corticotherapy. Finally, the administration of corticosteroids does not reduce maternal morbidity related to HELLP Syndrome