study of the association of schistosomal bladder cancer and HLA typing

ABSTRACT

Schistosomal bladder being the commonest solid malignant tumour in Egypt and being different from the transitional cell carcinoma of the bladder stimulated the present study to establish any association which may be present between it and HLA types. HLA typing was performed in 40 patients using the two stage lymphocytotoxicity method. Antisera supplied were used to define any of the 23 antigens at the HLA, A and B loci. Two control groups were included in our study the first was normal free controls and the second control group was schistosomal patients without any evidences of bladder cancer. The results of the present study showed absence of any association between schistosomal bladder cancer and any of the different 23 HLA antigens used