Comparison between the induction of anesthesia using sevoflurane-nitrous oxide, propofol or combination of propofol and sevoflurane-nitrous oxide using laryngeal mask airway [LMA] in hypertensive patients

ABSTRACT

In a double-blinded trial, 90 patients with stable hypertension were enrolled in this study. Each group consisted of 30 patients. The induction in group S was by sevoflurane 4% + 50% oxygen +50% nitrous oxide by inhalation using the tidal volume technique. The induction in group P was by propofol 2mg/kg IV, and in group PS [combination group] was by propofol 1mg/kg followed by inhalation of 4% sevoflurane.The present study compared hemodynamic changes, laryngeal mask airway [LMA] insertion time and any complications occurred in the induction period between the three groups. LMA insertion time was significantly longer in the sevoflurane group than in the other two groups. Mean arterial blood pressure [MAP] was significantly lower within each group after induction in comparison to before induction. In all the groups, LMA was successfully inserted in all patients. According to patients induction was pleasant in 90% of patients in the propofol group and was 88% in the combination group and 40% in the sevoflurane group. This study concluded that in the combination group there is the advantage of patient satisfaction and rapid induction with no apnea which occurred with propofol and had the advantage of hemodynamic stability encountered with sevoflurane