Dysmorphogenesis, clinical study

ABSTRACT

Dysmorphology describes the study of human congenital defects or abnormalities of body structure that originate before birth, dysmorphic anomalies can occur in any part of the body and most arise during the first 3 months of intrauterine life. Some of these anomalies are negligible or have only cosmetic significance, but about 3% of all children are burn with a serious structural defect that interferes with normal body function and can lead to lifelong handicap or even early death. To evaluate the prevalence, pattern of clinically detectable congenital anomalies among neonates, infants and children admitted to Assiut University Hospital. During a period of one and half years from January 2003 to June 2004, a total 9700 cases were admitted to AUH, 620 of them have a congenital malformation. They are segregated into 222 neonates, 269 infants and 129 children 119 babies have GIT anomalies, 129 have cardiac anomalies, and 75 have CNS anomalies and 86 with urogenital anomalies. The results spotlight that the incidence of dysmorphogenesis is high with father's age less than 40 years old age. The incidence of dysmorphogenesis is increased directly with number of pregnancies. The prematurity doesn't have adverse effect on the incidence of congenital anomalies. The incidence increased among babies came from rural area. Directly related to the maternal age showing low incidence with age magnitude and spectrum of dysmorphogenesis in our community. The main predisposing factors in our study were multiparty, family history of congenital and rural residence. This study may support the advanced age of mothers, consanguinity, paternal age and maternal medications