Comparative study of touch cytology and brush cytology with gastic biopsy and urease test for diagnosis of Helicobacter pylori

ABSTRACT

Detection of H. pylori, the widely distributed etiologic agent of gastro-duodenal inflammation, peptic ulcer and gastric cancer, is easy and available. In this study, 100 patients who visited endoscopy section of Imam Khomeini Hospital or private clinic in 2001 were studied for gastric cytology [brushing and touch preparation] and biopsy. Of 100 studied patients, 31 patients [31%] had abnormal endoscopy, including gastritis in 78%. Brushing was positive in 43 [43%] patients, touch preparation in 52 [52%], rapid urease test [RUT] in 53% and biopsy in 54[54%] of patients. Sensitivity of brush and touch cytology were 79.6% and96.3%, respectively. Agreement between brush and touch cytology was 78.1%. According to of Mc-Nemar test they had no concordance. Sensitivity of RUT was 98.1%. Agreement between touch cytology and biopsy was 96% and according to Mc-Nemar test they showed concordance