Study of antibiotics resistance in pediatric acute bacterial meningitis with E test method

ABSTRACT

Appropriate treatment of bacterial meningitis especially in children is a important problem due to multiple drug resistance. The determination MIC of conventional antibiotics for bacterial meningitis with quantitative E. test is exactly practical and essential. We studied MIC of conventional antibiotics in pediatric acute bacterial meningitis older than two months, center children hospital, 1382-1384. In this prospective and cross sectional process research we measured MIC of antibiotics in 30 positive bacterial culture in CSF or blood with quantitative E. test and compared with qualitative disk diffusion test. Antibiotic resistance of 10 Haemophilus influenzae type b patient was ampicillin resistance in 90%, co- Amoxiclave R. in 10%, chlorampheicol R. in 40%, third gerenation cephlosporins R.[ceftriaxone and cefotaxime] in 0% and cotrimoxazole R. in 100% and antibiotic resistance of 20 streptococcous pneumoniae patient was penicillin R. in 35%, chloramphenical R. in 10%, third generation cephalosporins R. in 5%,rifampin R. in 10% and cotrimoxazole R. in 60% .In comparison of two methods E-Test and Disk Diffusion we found insignificant difference. Antibiotic Resistance of our study is compatible with other studies. Therefore it seems that composition of ampicillin and chloramphenicol as empiric therapy for bacterial meningitis for many years ago,aren't appropriate today and third generation cephalosporins alone or with vancomycin is a suitable therapy