[Rando urinary proteinuria to creatinine ratio for predict of 24 hours proteinuria in women preeclampsia]

ABSTRACT

Preeclampsia occurs in approximately 5-12% of pregnancies, and its aetiology remains unknown. The most prevalent quantitative assessment of the amount of protein excreted in the urine for the diagnosis of preeclampsia is a 24-hour urine collection. However, the collection and analysis of 24-hour urine specimens is cumbersome and time consuming for both the patient and the laboratory. This study was undertaken to validate the prediction of 24-hour urine protein excretion by a single voided urine protein-to-creatinine [pc] ratio in a hospitalized pregnant population at our institution. This study was an analytical observation study investigation and was performed on 30 hospitalized pregrant women who were diagnosed as preeclampsia at 22 Bahman Hospital from 1382-1383. Pregnant patients who were admitted to the antepartum unit at 22-Bahman Hospital, and who were undergoing a 24-hour urine collection for the quantitation of proteinuria, were recruited. A single urine specimen was obtained after the completion of 24- hour urine collection and analyzed for the protein- to- creatinine ratio. Multiple linear regression was used to determine the correlation between the 24-hour urine protein excretion and spot urine protein-to-creatinine ratio. The strength of the association was assessed with the Pearson correlation coefficient. The correlation of the 24-hour urine protein and protein-to-creatinine ratio with other variables [including maternal age, gestational age, parity, blood pressure and weight] were assessed. Multiple linear regression was used to detect any confonuding effects. Thirty patients completed the study. There was a significant correlation between the 24-hour urine protein and the protein-to-creatinine ratio [r=85%, p<0/001]. The associations of maternal age, gestational age, weight, parity and blood pressure at the time of collection with protein-to-creatinine ratio and 24- hour urine protein were weak and not significant. On the basis of multiple linear regression, there was no confunding effect of maternal age, gestational age, parity, weight and blood pressure.Our data supports the use of single protein-to-creatinine ratio in hospitalized pregnant patients to predict the 24- hour urine protein result: