study on functional similarity between Denque non structural protein 1 and platelet integrin / adhesin protein, CD61

ABSTRACT

Dengue infection is a major public health problem. The mechanisms underlying severe bleeding in dengue DHF are not completely understood. It was proposed that the dengue virus nonstructural- 1 protein [DNS 1] generated antibodies to common epitopes on human blood clotting and integrinladhesin proteins on the platelet. The proof on the functional correlation between DNS 1 and platelet integrinladhesin proteins is needed. Here, the author used a new gene ontology technology to predict th molecular function and biological process of DNS 1 and platelet integrinladhesin proteir, CD6 1. According to this study, the author can identify no function and biological process of DNS1. Also, there is no existence of functional similarity between DNS1 and CD61. The hypothesis on role of molecular mimicry between DNS1 and CD61 is not supported in this study