Successful pregnancy following the removal of malignant endodermal sinus tumor and subsequent chemotherapy

ABSTRACT

Successful pregnancy in 29-year-old primigravid woman who presented in the department at the age of 16 year with ovarian, malignant, endodermal sinus [germ cell] tumor. She was operated on and a right salpingo-oophorectomy was performed. No evidence of local invasion or metastasis to the contra lateral ovary and the tumor had an intact capsule. Postoperatively, she was treated with three drugs combination chemotherapy [VAC]. Following her treatment there was no recurrences. Thirteen years later she became pregnant after two IVF cycles. We discuss in this report modern management of malignant germ cell tumors, their prognosis and the potential of subsequent resumption of reproductive function in these patients